Changes in nonhuman primate brain function following chronic alcohol consumption in previously naive animals.

ABSTRACT:

Introduction

Chronic alcohol abuse is associated with neurophysiological changes in brain activity; however, these changes are not well localized in humans. Non-human primate models of alcohol abuse enable control over many potential confounding variables associated with human studies. The present study utilized high-resolution magnetoencephalography (MEG) to quantify the effects of chronic EtOH self-administration on resting state (RS) brain function in vervet monkeys.

Methods

Adolescent male vervet monkeys were trained to self-administer ethanol (n=7) or an isocaloric malto-dextrin solution (n=3). Following training, animals received 12 months of free access to ethanol. Animals then underwent RS magnetoencephalography (MEG) and subsequent power spectral analysis of brain a

SUBMITTER: Rowland JA 

PROVIDER: S-EPMC5540330 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature