Reduction of Mosquito Survival in Mice Vaccinated with Anopheles stephensi Glucose Transporter.

ABSTRACT: Despite the fact that recent efforts to control/eradicate malaria have contributed to a significant decrease in the number of cases and deaths, the disease remains a global health challenge. Vaccines based on mosquito salivary gland antigens are a potential approach for reducing vector populations and malaria parasites. The Anopheles AGAP007752 gene encodes for a glucose transporter that is upregulated during Plasmodium infection, and its knockdown decreases the number of sporozoites in mosquito salivary glands. These results together with the fact that glucose is a vital source of energy suggested that a glucose transporter is a candidate protective antigen for the control of mosquito infestations and Plasmodium infection. To address this hypothesis, herein we investi

SUBMITTER: Couto J 

PROVIDER: S-EPMC5540378 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature