Ontology highlight
ABSTRACT:
SUBMITTER: Dardenne E
PROVIDER: S-EPMC5540451 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Dardenne Etienne E Beltran Himisha H Benelli Matteo M Gayvert Kaitlyn K Berger Adeline A Puca Loredana L Cyrta Joanna J Sboner Andrea A Noorzad Zohal Z MacDonald Theresa T Cheung Cynthia C Yuen Ka Shing KS Gao Dong D Chen Yu Y Eilers Martin M Mosquera Juan-Miguel JM Robinson Brian D BD Elemento Olivier O Rubin Mark A MA Demichelis Francesca F Rickman David S DS
Cancer cell 20161001 4
The transition from castration-resistant prostate adenocarcinoma (CRPC) to neuroendocrine prostate cancer (NEPC) has emerged as an important mechanism of treatment resistance. NEPC is associated with overexpression and gene amplification of MYCN (encoding N-Myc). N-Myc is an established oncogene in several rare pediatric tumors, but its role in prostate cancer progression is not well established. Integrating a genetically engineered mouse model and human prostate cancer transcriptome data, we sh ...[more]