Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.

ABSTRACT:

Background

Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD). The mechanism by which paracetamol may modulate the increased risk of developing ADHD is currently unknown. We have conducted an epigenome-wide association study (n = 384 cord blood samples) and investigated whether prenatal exposure to paracetamol is associated with DNA methylation in children diagnosed with ADHD.

Results

Analyses identified significant differences in DNA methylation (n = 6211 CpGs) associated with prenatal exposure to paracetamol for more than 20 days in children diagnosed with ADHD compared to controls. In addition, these samples were differentially methylated compared to sa

SUBMITTER: Gervin K 

PROVIDER: S-EPMC5540511 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature