Development of a core outcome set for clinical trials in facial aging: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey.

ABSTRACT:

Background

Facial aging is a concern for many patients. Wrinkles, loss of volume, and discoloration are common physical manifestations of aging skin. Genetic heritage, prior ultraviolet light exposure, and Fitzpatrick skin type may be associated with the rate and type of facial aging. Although many clinical trials assess the correlates of skin aging, there is heterogeneity in the outcomes assessed, which limits the quality of evaluation and comparison of treatment modalities. To address the inconsistency in outcomes, in this project we will develop a core set of outcomes that are to be evaluated in all clinical trials relevant to facial aging.

Methods/design

A long list of measureable outcomes will be created from four sources: (1) systematic medical literature review, (2) p

SUBMITTER: Schlessinger DI 

PROVIDER: S-EPMC5540562 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature