Proteomic analysis of hair shafts from monozygotic twins: Expression profiles and genetically variant peptides.

ABSTRACT: Forensic association of hair shaft evidence with individuals is currently assessed by comparing mitochondrial DNA haplotypes of reference and casework samples, primarily for exclusionary purposes. Present work tests and validates more recent proteomic approaches to extract quantitative transcriptional and genetic information from hair samples of monozygotic twin pairs, which would be predicted to partition away from unrelated individuals if the datasets contain identifying information. Protein expression profiles and polymorphic, genetically variant hair peptides were generated from ten pairs of monozygotic twins. Profiling using the protein tryptic digests revealed that samples from identical twins had typically an order of magnitude fewer protein expression differences than unrelated ind

SUBMITTER: Wu PW 

PROVIDER: S-EPMC5540574 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature