Brain plasticity and sensorimotor deterioration as a function of 70 days head down tilt bed rest.

ABSTRACT:

Background

Adverse effects of spaceflight on sensorimotor function have been linked to altered somatosensory and vestibular inputs in the microgravity environment. Whether these spaceflight sequelae have a central nervous system component is unknown. However, experimental studies have shown spaceflight-induced brain structural changes in rodents' sensorimotor brain regions. Understanding the neural correlates of spaceflight-related motor performance changes is important to ultimately develop tailored countermeasures that ensure mission success and astronauts' health.

Method

Head down-tilt bed rest (HDBR) can serve as a microgravity analog because it mimics body unloading and headward fluid shifts of microgravity. We conducted a 70-day 6° HDBR study with 18 right-handed males

SUBMITTER: Koppelmans V 

PROVIDER: S-EPMC5540603 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature