Plasma Proenkephalin and Poor Long-Term Outcome in Renal Transplant Recipients.

ABSTRACT:

Background

Proenkephalin (pro-ENK), a stable and reliable surrogate marker for unstable enkephalins, was found to be associated with acute kidney injury and chronic renal failure in previous studies. We aimed to investigate whether pro-ENK is linked to chronic kidney injury and poor long-term outcome in renal transplant recipients (RTR).

Methods

We included 664 stable RTR and 95 healthy kidney donors. Pro-ENK was measured in plasma with a double monoclonal sandwich immunoassay. Graft failure was defined as return to dialysis therapy or retransplantation.

Results

Median pro-ENK was 110 pmol/L (interquartile range [IQR], 85-148 pmol/L) in RTR and 48 pmol/L (IQR, 42-55 pmol/L) in kidney donors. Pro-ENK was correlated with estimated glomerular filtration rate (GFR) (r<

SUBMITTER: Kieneker LM 

PROVIDER: S-EPMC5540628 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature