Access to Heart Transplantation: A Proper Analysis of the Competing Risks of Death and Transplantation Is Required to Optimize Graft Allocation.

ABSTRACT:

Background

Heart allocation systems are usually urgency-based, offering grafts to candidates at high risk of waitlist mortality. In the context of a revision of the heart allocation rules, we determined observed predictors of 1-year waitlist mortality in France, considering the competing risk of transplantation, to determine which candidate subgroups are favored or disadvantaged by the current allocation system.

Methods

Patients registered on the French heart waitlist between 2010 and 2013 were included. Cox cause-specific hazards and Fine and Gray subdistribution hazards were used to determine candidate characteristics associated with waitlist mortality and access to transplantation.

Results

Of the 2053 candidates, 7 variables were associated with 1-year waitlist mor

SUBMITTER: Cantrelle C 

PROVIDER: S-EPMC5540636 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature