Long-term effects of severe acute malnutrition on lung function in Malawian children: a cohort study.

ABSTRACT: Early nutritional insults may increase risk of adult lung disease. We aimed to quantify the impact of severe acute malnutrition (SAM) on spirometric outcomes 7 years post-treatment and explore predictors of impaired lung function.Spirometry and pulse oximetry were assessed in 237 Malawian children (median age: 9.3 years) who had been treated for SAM and compared with sibling and age/sex-matched community controls. Spirometry results were expressed as z-scores based on Global Lung Function Initiative reference data for the African-American population.Forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) were low in all groups (mean FEV₁ z-score: -0.47 for cases, -0.48 for siblings, -0.34 for community controls; mean FVC z-score: -0.32, -0.38, and -0.15

SUBMITTER: Lelijveld N 

PROVIDER: S-EPMC5540677 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature