Risk of Second Malignancies in Solid Organ Transplant Recipients Who Develop Keratinocyte Cancers.

ABSTRACT: Solid organ transplant recipients have increased risk for developing keratinocyte cancers, including cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), in part as a result of immunosuppressive medications administered to prevent graft rejection. In the general population, keratinocyte cancers are associated with increased risks of subsequent malignancy, however, the risk in organ transplant populations has not been evaluated. We addressed this question by linking the U.S. Scientific Registry of Transplant Recipients, which includes data on keratinocyte cancer occurrence, with 15 state cancer registries. Risk of developing malignancies after keratinocyte cancer was assessed among 118,440 Caucasian solid organ transplant recipients using multivariate Cox regression model

SUBMITTER: Zamoiski RD 

PROVIDER: S-EPMC5540772 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature