Germline Genetic Variants and Lung Cancer Survival in African Americans.

ABSTRACT: Background: African Americans have the highest lung cancer mortality in the United States. Genome-wide association studies (GWASs) of germline variants influencing lung cancer survival have not yet been conducted with African Americans. We examined five previously reported GWAS catalog variants and explored additional genome-wide associations among African American lung cancer cases.Methods: Incident non-small cell lung cancer cases (N = 286) in the Southern Community Cohort Study were genotyped on the Illumina HumanExome BeadChip. We used Cox proportional hazards models to estimate HRs and 95% confidence intervals (CIs) for overall mortality. Two independent African American studies (N = 316 and 298) were used for replication.Results: One previously repo

SUBMITTER: Jones CC 

PROVIDER: S-EPMC5540773 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature