Airway and serum biochemical correlates of refractory neutrophilic asthma.

ABSTRACT:

Background

Despite progress in the diagnosis and management of asthma, many patients have poorly controlled or refractory asthma (RA). The mechanism of this RA is not well understood.

Objective

We sought to explore the relationship between neutrophils and other biomarkers of RA.

Method

Sixty patients with RA, 30 patients with nonrefractory asthma (NRA), and 20 healthy subjects were enrolled. We performed a comprehensive characterization of these study subjects, which included laboratory and pulmonary function studies, chest computed tomography, and bronchoscopy with bronchoalveolar lavage (BAL). We analyzed BAL fluid and serum for a total of 244 biomolecules using a multiplex assay and correlated them with clinical and other laboratory parameters.

Results

RA wa

SUBMITTER: Alam R 

PROVIDER: S-EPMC5540819 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature