Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells.

ABSTRACT: Standard of care for Epithelial Ovarian Cancer (EOC) patients relies on platinum-based therapy. However, acquired resistance to platinum occurs frequently and predicts poor prognosis. To understand the mechanisms underlying acquired platinum-resistance, we have generated and characterized three platinum-resistant isogenic EOC cell lines. Resistant cells showed 3-to 5- folds increase in platinum IC50. Cross-resistance to other chemotherapeutic agents commonly used in the treatment of EOC patients was variable and dependent on the cell line utilized. Gene expression profiling (GEP) of coding and non-coding RNAs failed to identify a common signature that could collectively explain the mechanism of resistance. However, we observed that all resistant cell lines displayed a decreased level of DN

SUBMITTER: Sonego M 

PROVIDER: S-EPMC5540908 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature