MiR-155 Regulates IL-10-Producing CD24^hiCD27⁺ B Cells and Impairs Their Function in Patients with Crohn's Disease.

ABSTRACT: Regulatory interleukin-10 (IL-10)-producing B cells (B10 cells) play a critical role in preventing and curing autoimmune diseases in experimental mouse models. However, the precise cellular and molecular mechanisms of action of B10 cells in humans, especially in patients with Crohn's disease (CD), remain to be determined. miR-155 regulates many physiological and pathological conditions, including inflammation such as that in CD. In this study, we aimed to explore the effect of miRNA-155 on IL-10 production by B cells in healthy controls (HCs) and CD patients. Interestingly, we found that CD24^hiCD27⁺ B cells express high levels of miRNA-155 and IL-10, which are positively correlated. Additionally, CD24^hiCD27⁺ B cells express higher levels of Toll-

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC5540954 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature