Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain.

ABSTRACT:

Background

In human carcinomas, overexpression of cortactin correlates with poor prognosis. Cortactin is an F-actin-binding protein involved in cytoskeletal rearrangements and cell migration by promoting actin-related protein (Arp)2/3 mediated actin polymerization. It shares a high amino acid sequence and structural similarity to hematopoietic lineage cell-specific protein 1 (HS1) although their functions differ considerable. In this manuscript we describe the genomic organization of these two genes in a variety of species by a combination of cloning and database searches. Based on our analysis, we predict the genesis of the actin-binding repeat domain during evolution.

Results

Cortactin homologues exist in sponges, worms, shrimps, insects, urochordates, fishes, amphibians,

SUBMITTER: van Rossum AG 

PROVIDER: S-EPMC554100 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature