Aryl hydrocarbon receptor (AHR) is a potential tumour suppressor in pituitary adenomas.

ABSTRACT: Pituitary adenomas (PA) represent the largest group of intracranial neoplasms and yet the molecular mechanisms driving this disease remain largely unknown. The aim of this study was to use a high-throughput screening method to identify molecular pathways that may be playing a significant and consistent role in PA. RNA profiling using microarrays on eight local PAs identified the aryl hydrocarbon receptor (AHR) signalling pathway as a key canonical pathway downregulated in all PA types. This was confirmed by real-time PCR in 31 tumours. The AHR has been shown to regulate cell cycle progression in various cell types; however, its role in pituitary tissue has never been investigated. In order to validate the role of AHR in PA behaviour, further functional studies were undertaken. Over-express

SUBMITTER: Formosa R 

PROVIDER: S-EPMC5541251 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature