Ontology highlight
ABSTRACT: Background
The present study retrospectively evaluated the chronology and predictors of substance use progression in current heroin-using individuals.Methods
Out-of-treatment heroin users (urinalysis-verified; N=562) were screened for laboratory-based research studies using questionnaires and urinalysis. Comprehensive substance use histories were collected. Between- and within-substance use progression was analyzed using stepwise linear regression models.Results
The strongest predictor of onset of regular heroin use was age at initial heroin use, accounting for 71.8% of variance. The strongest between-substance predictors of regular heroin use were ages at regular alcohol and tobacco use, accounting for 8.1% of variance. Earlier onset of regular heroin use (≤20 years) vs. older onset (≥30 years) was associated with a more rapid progression from initial to regular use, longer duration of heroin use, more lifetime use-related negative consequences, and greater likelihood of injecting heroin. The majority of participants (79.7%) reported substance use progression consistent with the gateway hypothesis. Gateway-inconsistent individuals were more likely to be African-American and to report younger age at initial use, longer duration of heroin use, and more frequent past-month heroin use.Conclusions
Our findings demonstrate the predictive validity and clinical relevance of evaluating substance use chronology and the gateway hypothesis pattern of progression.
SUBMITTER: Woodcock EA
PROVIDER: S-EPMC5541382 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Woodcock Eric A EA Lundahl Leslie H LH Stoltman Jonathan J K JJ Greenwald Mark K MK
Addictive behaviors 20150226
<h4>Background</h4>The present study retrospectively evaluated the chronology and predictors of substance use progression in current heroin-using individuals.<h4>Methods</h4>Out-of-treatment heroin users (urinalysis-verified; N=562) were screened for laboratory-based research studies using questionnaires and urinalysis. Comprehensive substance use histories were collected. Between- and within-substance use progression was analyzed using stepwise linear regression models.<h4>Results</h4>The stron ...[more]