Pan-genome and phylogeny of Bacillus cereus sensu lato.

ABSTRACT:

Background

Bacillus cereus sensu lato (s. l.) is an ecologically diverse bacterial group of medical and agricultural significance. In this study, I use publicly available genomes and novel bioinformatic workflows to characterize the B. cereus s. l. pan-genome and perform the largest phylogenetic and population genetic analyses of this group to date in terms of the number of genes and taxa included. With these fundamental data in hand, I identify genes associated with particular phenotypic traits (i.e., "pan-GWAS" analysis), and quantify the degree to which taxa sharing common attributes are phylogenetically clustered.

Methods

A rapid k-mer based approach (Mash) was used to create reduced representations of selected Bacillus genomes, and a fast distance-based phylogenetic ana

SUBMITTER: Bazinet AL 

PROVIDER: S-EPMC5541404 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature