Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis.

ABSTRACT:

Background

The criteria for defining severe malaria have evolved over the last 20 years. We aimed to assess the strength of association of death with features currently characterizing severe malaria through a systematic review and meta-analysis.

Method

Electronic databases (Medline, Embase, Cochrane Database of Systematic Reviews, Thomson Reuters Web of Knowledge) were searched to identify publications including African children with severe malaria. PRISMA guidelines were followed. Selection was based on design (epidemiological, clinical and treatment studies), setting (Africa), participants (children < 15 years old with severe malaria), outcome (survival/death rate), and prognostic indicators (clinical and laboratory features). Quality assessment was performed following the

SUBMITTER: Sypniewska P 

PROVIDER: S-EPMC5541406 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature