Down-regulation of metabolic proteins in hepatocellular carcinoma with portal vein thrombosis.

ABSTRACT:

Background

Hepatocellular carcinoma is an aggressive malignancy with poor prognosis and easy to recur even the tumor is totally removed by surgery. Portal vascular invasion is one of the major factors contributing to tumor recurrence and poor prognosis. However, why hepatocellular carcinoma is easy to grow into vessels is unclear.

Methods

Surgical specimens from seven hepatocellular carcinoma patients with portal vein thrombosis and seven patients without vascular invasion were utilized to analyze protein expression by proteomic technique. The proteins in the tumors were separated by 2-dimensional electrophoresis. Protein patterns in the gels were recorded as digitalized images. The differences of expression in hepatocellular carcinoma with or without portal vein thrombosis

SUBMITTER: Lee WC 

PROVIDER: S-EPMC5541415 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature