Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas.

ABSTRACT: The epithelial-to-mesenchymal transition (EMT) is a cell biological program that confers mesenchymal traits on carcinoma cells and drives their metastatic dissemination. It is unclear, however, whether the activation of EMT in carcinoma cells can change their susceptibility to immune attack. We demonstrate here that mammary tumor cells arising from more epithelial carcinoma cell lines expressed high levels of MHC-I, low levels of PD-L1, and contained within their stroma CD8⁺ T cells and M1 (antitumor) macrophages. In contrast, tumors arising from more mesenchymal carcinoma cell lines exhibiting EMT markers expressed low levels of MHC-I, high levels of PD-L1, and contained within their stroma regulatory T cells, M2 (protumor) macrophages, and exhausted CD8⁺ T cells. Mo

SUBMITTER: Dongre A 

PROVIDER: S-EPMC5541771 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature