Hic-5 remodeling of the stromal matrix promotes breast tumor progression.

ABSTRACT: The remodeling of the stromal extracellular matrix (ECM) has a crucial, but incompletely understood role during tumor progression and metastasis. Hic-5, a focal adhesion scaffold protein, has previously been implicated in tumor cell invasion, proliferation and metastasis. To investigate the role of Hic-5 in breast tumor progression in vivo, Hic-5^-/- mice were generated and crossed with the Mouse Mammary Tumor Virus-Polyoma Middle T-Antigen mouse. Tumors from the Hic-5^-/-;PyMT mice exhibited increased latency and reduced growth, with fewer lung metastases, as compared with Hic-5^+/-;PyMT mice. Immunohistochemical analysis showed that Hic-5 is primarily expressed in the cancer-associated fibroblasts (CAFs). Further analysis revealed that the Hic-5^-/-

SUBMITTER: Goreczny GJ 

PROVIDER: S-EPMC5541773 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature