Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.

ABSTRACT:

Introduction

It is unclear whether patients diagnosed according to International Classification of Headache Disorders criteria for migraine with aura (MA) and migraine without aura (MO) experience distinct disorders or whether their migraine subtypes are genetically related.

Aim

Using a novel gene-based (statistical) approach, we aimed to identify individual genes and pathways associated both with MA and MO.

Methods

Gene-based tests were performed using genome-wide association summary statistic results from the most recent International Headache Genetics Consortium study comparing 4505 MA cases with 34,813 controls and 4038 MO cases with 40,294 controls. After accounting for non-independence of gene-based test results, we examined the significance of the proportion of

SUBMITTER: Zhao H 

PROVIDER: S-EPMC5541777 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature