Hydrogel Patches on Live Cells through Surface-Mediated Polymerization.

ABSTRACT: Many naturally occurring cells possess an intrinsic ability to cross biological barriers that block conventional drug delivery, and these cells offer a possible mode of active transport across the blood-brain barrier or into the core of tumor masses. While many technologies for the formation of complete, nanoparticle-loaded coatings on cells exist, a complete coating on the cell surface would disrupt the interaction of cells with their environments. To address this issue, cell surface patches that partially cover cell surfaces might provide a superior approach for cell-mediated therapeutic delivery. The goal of this study is to establish a simplified approach to producing polymeric patches of arbitrary shapes on a live cell via surface-mediated photopolymerization. Cell surfaces were nonsp

SUBMITTER: Wu PJ 

PROVIDER: S-EPMC5541780 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature