Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion.

ABSTRACT:

Background

Prior studies suggest that renin-angiotensin-aldosterone system (RAAS) inhibitors decrease parathyroid hormone (PTH) secretion.

Objective

To evaluate the effect of angiotensin-converting enzyme inhibitors (ACEi) on serum PTH in participants with and without primary hyperparathyroidism (P-HPT).

Methods

An open-label, single-arm, pilot study whereby participants with and without P-HPT had PTH were evaluated before and after 1 week of maximally tolerated lisinopril therapy.

Results

A total of 12 participants with, and 15 participants without, P-HPT successfully completed the protocol. Following 1 week of lisinopril, participants with P-HPT had a decrease in systolic blood pressure (SBP) (-6.4 mmHg, P < 0.01), an increase in plasma renin activity

SUBMITTER: Zaheer S 

PROVIDER: S-EPMC5541811 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature