Systems-wide Studies Uncover Commander, a Multiprotein Complex Essential to Human Development.

ABSTRACT: Recent mass spectrometry maps of the human interactome independently support the existence of a large multiprotein complex, dubbed "Commander." Broadly conserved across animals and ubiquitously expressed in nearly every human cell type examined thus far, Commander likely plays a fundamental cellular function, akin to other ubiquitous machines involved in expression, proteostasis, and trafficking. Experiments on individual subunits support roles in endosomal protein sorting, including the trafficking of Notch proteins, copper transporters, and lipoprotein receptors. Commander is critical for vertebrate embryogenesis, and defects in the complex and its interaction partners disrupt craniofacial, brain, and heart development. Here, we review the synergy between large-scale proteomic efforts an

SUBMITTER: Mallam AL 

PROVIDER: S-EPMC5541947 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature