Ontology highlight
ABSTRACT:
SUBMITTER: Burgess MR
PROVIDER: S-EPMC5541948 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Cell 20170216 5
Investigating therapeutic "outliers" that show exceptional responses to anti-cancer treatment can uncover biomarkers of drug sensitivity. We performed preclinical trials investigating primary murine acute myeloid leukemias (AMLs) generated by retroviral insertional mutagenesis in Kras<sup>G12D</sup> "knockin" mice with the MEK inhibitor PD0325901 (PD901). One outlier AML responded and exhibited intrinsic drug resistance at relapse. Loss of wild-type (WT) Kras enhanced the fitness of the dominant ...[more]