Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma.

ABSTRACT:

Purpose

This study aims to determine the functional role of S100A15 and its promoter DNA methylation patterns in lung cancer progression.

Experimental design

We analyzed 178 formalin-fixed paraffin embedded specimens from lung cancer patients, including 24 early stage and 91 advanced stage adenocarcinoma. S100A15 protein expression was evaluated by immunohistochemistry stain, and its DNA methylation levels were measured by pyrosequencing.

Results

S100A15 nuclear staining was increased in lung adenocarcinoma patients with distant metastasis versus those without distant metastasis. There was reduced one/three-year overall survival in adenocarcinoma patients receiving first line target therapy and harboring high nuclear expressions of S100A15. Both DNA methylation levels

SUBMITTER: Chen YC 

PROVIDER: S-EPMC5542220 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature