Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.

ABSTRACT: The progression of CRC is a multistep process involving several genetic changes or epigenetic modifications. NDN is a member of the MAGE family, encoding a protein that generally suppresses cell proliferation and acting as a transcriptional repressor. Immunohistochemical staining revealed that the expression of NDN was significantly down-regulated in CRC tissues compared with normal tissues and the down-regulation of NDN in CRC could reflect the hypermethylation of the NDN promoter. Treatment of the CRC cell line SW480 with the demethylating agent 5-Aza-CdR restored the NDN expression level. The down-regulation of NDN was closely related to poor differentiation, advanced TNM stage and poor prognosis of CRC. The inhibition of NDN promoted CRC cell proliferation by enriching cells in the S p

SUBMITTER: Hu YH 

PROVIDER: S-EPMC5542259 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature