Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma.

ABSTRACT:

Background

The p16Ink4a is not a surrogate marker for high-risk human papilloma virus (HPV) genotypes but indicates better prognosis in vulvar squamous cell carcinoma patients. Our recent study confirmed substantial mismatch between p16Ink4a and high-risk HPV-status as well as revealed that p16Ink4a-overexpression itself is an independent prognostic factor for vulvar cancer.

Aim

To determine significance of the tumor infiltrating immune cells and p16Ink4a-status for better outcome of patients with vulvar cancer.

Methods

Intraepithelial tumor infiltrating lymphocytes: CD8+, CD4+, FOXP3+, CD56+, tumor associated macrophages: CD68+, and GZB+ cells were calculated in 85 vulvar squamous cell carcinomas with previously defined p16Ink4a and high-risk HPV-status. Number of in

SUBMITTER: Sznurkowski JJ 

PROVIDER: S-EPMC5542260 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature