The impact of thyroid hormones on patients with hepatocellular carcinoma.

ABSTRACT:

Background & aims

Hypothyroidism has recently been proposed as predisposing factor for HCC development. However, the role of thyroid hormones (TH) in established HCC is largely unclear. We investigated the impact of TH on clinical characteristics and prognosis of HCC patients.

Methods

Of 838 patients diagnosed with nonsurgical HCC at the Division of Gastroenterology and Hepatology/Medical University of Vienna between 1992 and 2012, 667 patients fulfilled the inclusion criteria. The associations of thyroid function tests with patient, liver, and tumor characteristics as well as their impact on overall survival (OS) were investigated.

Results

Thyroid hormone substitution was more often observed in patients with low thyroid-stimulating hormone (TSH) concentration and in

SUBMITTER: Pinter M 

PROVIDER: S-EPMC5542594 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature