MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension.

ABSTRACT:

Background

In older adults (aged 70-74 years), African-Americans have 4-fold higher risk of developing hypertension-attributed end-stage renal disease (ESRD) than European-Americans. A hypothesized mechanism linking hypertension and progressive chronic kidney disease (CKD) is the innate immune response and inflammation. Persons with CKD are also more susceptible to infection. Gene expression in peripheral blood can provide a view of the innate immune activation profile. We aimed to identify differentially expressed genes, microRNAs, and pathways in peripheral blood between cases with CKD and high blood pressure under hypertension treatment versus controls without CKD and with controlled blood pressure in African Americans.

Methods

Case and control pairs (N = 15x2) were selec

SUBMITTER: Nandakumar P 

PROVIDER: S-EPMC5542606 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature