Cholecystectomy can increase the risk of colorectal cancer: A meta-analysis of 10 cohort studies.

ABSTRACT:

Objective

This study aimed to elucidate the effects of cholecystectomy on the risk of colorectal cancer (CRC) by conducting a meta-analysis of 10 cohort studies.

Methods

The eligible cohort studies were selected by searching the PubMed and EMBASE databases from their origination to June 30, 2016, as well as by consulting the reference lists of the selected articles. Two authors individually collected the data from the 10 papers. When the data showed marked heterogeneity, we used a random-effects model to estimate the overall pooled risk; otherwise, a fixed effects model was employed.

Results

The final analysis included ten cohort studies. According to the Newcastle-Ottawa Scale (NOS), nine papers were considered high quality. After the data of these 9 studies were com

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5542607 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature