18F-FDG-PET/CT for the detection of disease in patients with head and neck cancer treated with radiotherapy.

ABSTRACT:

Objective

The aim of this study is to evaluate the diagnostic performance of FDG-PET/CT for the detection of residual disease after (chemo)radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) and to evaluate the prognostic value of the FDG-PET/CT findings.

Methods

Patients with HNSCC who underwent FDG-PET/CT after (chemo)radiotherapy were studied retrospectively.

Results

104 FDG-PET/CT-scans were performed at a median of 13.2 weeks post-treatment (5.4-19.0 weeks). The diagnostic performance was time dependent with decreasing sensitivity and slightly increasing specificity over time. Sensitivity, specificity, PPV and NPV at 9 months after imaging were 91%, 87%, 77% and 95%, respectively. In a logistic regression model, the odds of a correct FDG-P

SUBMITTER: Helsen N 

PROVIDER: S-EPMC5542639 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature