Primary graft dysfunction: pathophysiology to guide new preventive therapies.

ABSTRACT:

Introduction

Primary graft dysfunction (PGD) is a common complication of lung transplantation characterized by acute pulmonary edema associated with bilateral pulmonary infiltrates and hypoxemia in the first 3 post-operative days. Development of PGD is a predictor of poor short- and long-term outcomes after lung transplantation, but there are currently limited tools to prevent its occurrence. Areas covered: Several potentially modifiable donor, recipient, and operative risk factors for PGD have been identified. In addition, basic and translational studies in animals and ex vivo lung perfusion systems have identified several biomarkers and mechanisms of injury in PGD. In this review, we outline the clinical and genetic risk factors for PGD and summarize experimental data exploring P

SUBMITTER: Shaver CM 

PROVIDER: S-EPMC5542681 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature