Differentiating heart failure phenotypes using sex-specific transcriptomic and proteomic biomarker panels.

ABSTRACT:

Aims

Heart failure with preserved ejection fraction (HFpEF) accounts for 30-50% of patients with heart failure (HF). A major obstacle in HF management is the difficulty in differentiating between HFpEF and heart failure with reduced ejection fraction (HFrEF) using conventional clinical and laboratory investigations. The aim of this study is to develop robust transcriptomic and proteomic biomarker signatures that can differentiate HFpEF from HFrEF.

Methods and results

A total of 210 HF patients were recruited in participating institutions from the Alberta HEART study. An expert clinical adjudicating panel differentiated between patients with HFpEF and HFrEF. The discovery cohort consisted of 61 patients, and the replication cohort consisted of 70 patients. Transcriptomic and

SUBMITTER: Toma M 

PROVIDER: S-EPMC5542716 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature