Cationic Supramolecular Hydrogels for Overcoming the Skin Barrier in Drug Delivery.

ABSTRACT: A cationic bis-imidazolium-based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the gelator and the type and concentration of the drug incorporated were found to be factors that strongly influenced the gelling temperature, gel-formation period, and overall stability and morphology. The incorporation of brimonidine tartrate resulted in the formation of the most homogeneous material of the three drugs explored, whereas the incorporation of betamethasone resulted in a gel with a completely different morphology comprising linked particles. NMR spectroscopy studies proved that these gels kept the drug not only at the interstitial space but also within the fib

SUBMITTER: Limon D 

PROVIDER: S-EPMC5542755 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature