Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a.

ABSTRACT:

Rationale

Inflammation is a key contributor to atherosclerosis. MicroRNA-146a (miR-146a) has been identified as a critical brake on proinflammatory nuclear factor κ light chain enhancer of activated B cells signaling in several cell types, including endothelial cells and bone marrow (BM)-derived cells. Importantly, miR-146a expression is elevated in human atherosclerotic plaques, and polymorphisms in the miR-146a precursor have been associated with risk of coronary artery disease.

Objective

To define the role of endogenous miR-146a during atherogenesis.

Methods and results

Paradoxically, Ldlr^-/- (low-density lipoprotein receptor null) mice deficient in miR-146a develop less atherosclerosis, despite having highly elevated levels of circu

SUBMITTER: Cheng HS 

PROVIDER: S-EPMC5542783 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature