Efficacy of Sodium Hyaluronate in Murine Diabetic Ocular Surface Diseases.

ABSTRACT:

Purpose

To evaluate the efficacy of sodium hyaluronate (HA) eye drops for the treatment of diabetic ocular surface diseases in mice.

Methods

Male 6- to 8-week-old C57BL/6 mice underwent induction of type 1 diabetes with intraperitoneal injections of streptozotocin, with normal mice as the control. Topical 0.3% HA, 0.1% HA, 0.4% polyethylene glycol eye drops, and normal saline were administered to diabetic mice with an intact or debrided corneal epithelium. Normal saline was applied in the controls. Corneal epithelial wound healing rate, corneal sensation, nerve fiber density, conjunctival goblet cell number, and MUC-5AC content were measured and compared.

Results

Compared with the controls, topical 0.3% HA use in diabetic mice showed significant improvements in the co

SUBMITTER: Di G 

PROVIDER: S-EPMC5542787 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature