Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9.

ABSTRACT: CRISPR/Cas9 genome editing can facilitate efficient deletion of genomic region, but it has not been used to delete an entire chromosome. Here, Adikusuma et al. show proof-of-concept for efficient CRISPR-mediated selective chromosome deletion by removing the centromere or shredding the chromosome arm in mouse embryonic stem cells and zygotes.

SUBMITTER: Adikusuma F 

PROVIDER: S-EPMC5542798 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature