Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging.

ABSTRACT: Microglia, the principal resident immune cell in the retina, play constitutive roles in immune surveillance and synapse maintenance, and are also associated with retinal disease, including those occurring in the macula. Perspectives on retinal microglia function have derived largely from rodent models and how these relate to the macula-bearing primate retina is unclear. In this study, we examined microglial distribution and cellular morphology in the adult rhesus macaque retina, and performed comparative characterizations in three retinal locations along the center-to-periphery axis (parafoveal, macular, and the peripheral retina). We found that microglia density peaked in the parafoveal retina and decreased in the peripheral retina. Individual microglial morphology reflected macular speci

SUBMITTER: Singaravelu J 

PROVIDER: S-EPMC5542874 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature