Immunological Properties of Murine Parthenogenetic Stem Cells and Their Differentiation Products.

ABSTRACT: The perspective to transplant grafts derived from pluripotent stem cells has gained much attention in recent years. Parthenogenetic stem cells (PSCs) are an alternative pluripotent stem cell type that is attractive as source of grafts for allogeneic transplantations because most PSCs are haploidentical for the major histocompatibility complex (MHC). This reduced immunogenetic complexity of PSCs could tremendously simplify the search for MHC-matched allogeneic stem cells. In this study, we have characterized immunological properties of the MHC haploidentical PSC line A3 (H2^d/d) and the heterologous PSC line A6 (H2^b/d). Both PSC lines largely lack MHC class I molecules, which present peptides to cytotoxic T lymphocytes (CTLs) and serve as ligands for inhibitory natural

SUBMITTER: Johannsen H 

PROVIDER: S-EPMC5543037 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature