Enriching Traditional Protein-protein Interaction Networks with Alternative Conformations of Proteins.

ABSTRACT: Traditional Protein-Protein Interaction (PPI) networks, which use a node and edge representation, lack some valuable information about the mechanistic details of biological processes. Mapping protein structures to these PPI networks not only provides structural details of each interaction but also helps us to find the mutual exclusive interactions. Yet it is not a comprehensive representation as it neglects the conformational changes of proteins which may lead to different interactions, functions, and downstream signalling. In this study, we proposed a new representation for structural PPI networks inspecting the alternative conformations of proteins. We performed a large-scale study by creating breast cancer metastasis network and equipped it with different conformers of proteins. Our res

SUBMITTER: Halakou F 

PROVIDER: S-EPMC5543104 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature