High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling.

ABSTRACT: Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system. Here, using contrast enhanced micro-computed tomography, we present, in attitudinally appropriate fashion, the first 3-dimensional representations of the cardiac conduction system within the intact human heart. We show that cardiomyocyte orientation can be extracted from these datasets at spatial resolutions approaching the single cell. These data show that commonly accepted anatomical representations are oversimplified. We have incorporated the high-resolution anatomical data into mathematical simulations of cardiac electrical depolarisation. The data presented should have multidisciplinary impact. Since the rate o

SUBMITTER: Stephenson RS 

PROVIDER: S-EPMC5543124 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature