Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells.

ABSTRACT: Glycyrrhizic acid (GA), the major bioactive triterpene glycoside of glycyrrhiza, has been shown to possess a wide range of pharmacological properties, including anti-inflammatory and anti-viral properties. However, few studies have examined the anti-allergic activity and exact mechanism of action of GA. In the present work, the anti-allergic activity and possible mechanisms of action of GA on an immunoglobulin (Ig) E-mediated allergic reaction has been studied using three models of allergic reaction in vivo and in vitro. Active systemic allergic reaction in Balb/c mice showed that GA can suppress the increased level of IL-4 to restore the immune balance of T_H1/T_H2 cells in a dose-dependent manner. Additionally, GA attenuated significantly the B cells producing allerge

SUBMITTER: Han S 

PROVIDER: S-EPMC5543155 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature