Effect of Expedited Microneedle-Assisted Photodynamic Therapy for Field Treatment of Actinic Keratoses: A Randomized Clinical Trial.

ABSTRACT:

Importance

Photodynamic therapy (PDT) is an effective and cosmetically favorable treatment modality for actinic keratoses (AKs). However, prolonged incubation times and pain associated with treatment are burdensome to the patient and a hindrance to widespread use of PDT as standard field therapy for AK.

Objective

To evaluate efficacy and pain associated with microneedle expedited PDT.

Design, setting, and participants

The Microneedle Photodynamic Therapy II (MNPDT-II) study was a randomized, single-blinded, split-face controlled, 2-arm clinical trial. Thirty-three participants with AK on the face were recruited in a university dermatology outpatient clinic from 2015 to 2016, and 32 participants completed the study.

Interventions

Participants were randomized int

SUBMITTER: Petukhova TA 

PROVIDER: S-EPMC5543325 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature