Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location.

ABSTRACT:

Objectives

Evidence suggests a possible role of Fusobacterium nucleatum in colorectal carcinogenesis, especially in right-sided proximal colorectum. Considering a change in bowel contents and microbiome from proximal to distal colorectal segments, we hypothesized that the proportion of colorectal carcinoma enriched with F. nucleatum might gradually increase along the bowel subsites from rectum to cecum.

Methods

A retrospective, cross-sectional analysis was conducted on 1,102 colon and rectal carcinomas in molecular pathological epidemiology databases of the Nurses' Health Study and the Health Professionals Follow-up Study. We measured the amount of F. nucleatum DNA in colorectal tumor tissue using a quantitative PCR assay and equally dichotomized F. nucleatum-positive cases

SUBMITTER: Mima K 

PROVIDER: S-EPMC5543402 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature