Fungal endophytes associated with Viola odorata Linn. as bioresource for pancreatic lipase inhibitors.

ABSTRACT:

Background

As per the recent statistical reports of World Health Organisation (WHO), 13% of total global population is obese. Orlistat remains to be the only drug approved for the long term treatment of obesity. Recent findings highlighted severe adverse effects of orlistat that included hepatotoxicity, gall stones, kidney stones and acute pancreatitis. Therefore, search for new drug is required. The investigations based on endophytic natural products would prove pivotal in the global fight against this health issue.

Methods

Obesity is associated with lipid metabolism involving pancreatic lipase enzyme. The inhibition of pancreatic lipase is demonstrated by using the extracts of endophytes isolated from Viola odorata Linn. In addition, endophytes were identified using ITS ba

SUBMITTER: Katoch M 

PROVIDER: S-EPMC5543550 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature