Characterization of long-term gait deficits in mouse dMCAO, using the CatWalk system.

ABSTRACT: Evaluation of functional outcome is widely used across species to assess the recovery process following various pathological conditions, including spinal cord injury, musculo-skeletal injury, mithochondrial disease, neuropathic cancer, Huntington's disease, chronic pain, cortical lesion, and olivocerebellar degeneration among others. The Stroke Therapy Academic Industry Roundtable (STAIR) recommends multiple endpoints for behavioral studies in pre-clinical stroke research, to demonstrate their clinical relevance. One of the more challenging tasks in experimental stroke research is measuring long-term functional outcome in mice. It is, however, becoming more important, since transgenic mice are increasingly used for modeling human neurological disorders. Using CatWalk, we characterized long

SUBMITTER: Caballero-Garrido E 

PROVIDER: S-EPMC5543803 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature